Closed-loop deep brain stimulation is superior in ameliorating parkinsonism.
Identifieur interne : 001703 ( Main/Exploration ); précédent : 001702; suivant : 001704Closed-loop deep brain stimulation is superior in ameliorating parkinsonism.
Auteurs : Boris Rosin [Israël] ; Maya Slovik ; Rea Mitelman ; Michal Rivlin-Etzion ; Suzanne N. Haber ; Zvi Israel ; Eilon Vaadia ; Hagai BergmanSource :
- Neuron [ 1097-4199 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Basal Ganglia (physiopathology), Cercopithecus aethiops, Deep Brain Stimulation (methods), Globus Pallidus (physiopathology), MPTP Poisoning (chemically induced), MPTP Poisoning (physiopathology), MPTP Poisoning (therapy), Neurons (physiology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (physiopathology), Parkinson Disease, Secondary (therapy), Treatment Outcome.
- MESH :
- chemically induced : MPTP Poisoning, Parkinson Disease, Secondary.
- methods : Deep Brain Stimulation.
- physiology : Neurons.
- physiopathology : Basal Ganglia, Globus Pallidus, MPTP Poisoning, Parkinson Disease, Secondary.
- therapy : MPTP Poisoning, Parkinson Disease, Secondary.
- Animals, Cercopithecus aethiops, Treatment Outcome.
Abstract
Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson's disease (PD) management. However, the mechanisms underlying DBS effects remain enigmatic and are the subject of an ongoing debate. Here, we present and test a closed-loop stimulation strategy for PD in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model of PD. Application of pallidal closed-loop stimulation leads to dissociation between changes in basal ganglia (BG) discharge rates and patterns, providing insights into PD pathophysiology. Furthermore, cortico-pallidal closed-loop stimulation has a significantly greater effect on akinesia and on cortical and pallidal discharge patterns than standard open-loop DBS and matched control stimulation paradigms. Thus, closed-loop DBS paradigms, by modulating pathological oscillatory activity rather than the discharge rate of the BG-cortical networks, may afford more effective management of advanced PD. Such strategies have the potential to be effective in additional brain disorders in which a pathological neuronal discharge pattern can be recognized.
DOI: 10.1016/j.neuron.2011.08.023
PubMed: 22017994
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for advanced Parkinson's disease (PD) management. However, the mechanisms underlying DBS effects remain enigmatic and are the subject of an ongoing debate. Here, we present and test a closed-loop stimulation strategy for PD in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model of PD. Application of pallidal closed-loop stimulation leads to dissociation between changes in basal ganglia (BG) discharge rates and patterns, providing insights into PD pathophysiology. Furthermore, cortico-pallidal closed-loop stimulation has a significantly greater effect on akinesia and on cortical and pallidal discharge patterns than standard open-loop DBS and matched control stimulation paradigms. Thus, closed-loop DBS paradigms, by modulating pathological oscillatory activity rather than the discharge rate of the BG-cortical networks, may afford more effective management of advanced PD. Such strategies have the potential to be effective in additional brain disorders in which a pathological neuronal discharge pattern can be recognized.</div>
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<name sortKey="Mitelman, Rea" sort="Mitelman, Rea" uniqKey="Mitelman R" first="Rea" last="Mitelman">Rea Mitelman</name>
<name sortKey="Rivlin Etzion, Michal" sort="Rivlin Etzion, Michal" uniqKey="Rivlin Etzion M" first="Michal" last="Rivlin-Etzion">Michal Rivlin-Etzion</name>
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<name sortKey="Vaadia, Eilon" sort="Vaadia, Eilon" uniqKey="Vaadia E" first="Eilon" last="Vaadia">Eilon Vaadia</name>
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